Okay, so here's how you make a cat girl. Don't genetically modify a girl for cat like features. We can't do that yet. Selectively breed humans to give you a young girl with anime like features, and raise her in isolation so she trusts you and only you. Make her think animes are examples of how people really behave. Formulate a strict diet and exercise plan so she's always in the exact physical form you wish. Humans have a "growth hormone". Excess of this causes giganticism. I'm absolutely sure cats have a similar hormone, which scientists are probably already aware of. If not, finding it should be doable. Not easy, science is never easy, but doable with current technology. Find the breed of cat with ears and tail that best matches your aesthetic preferences, and fur the colour you want. Take young, healthy, robust specimens and inject the growth hormone directly into their circulatory system, in a large vein, not an extremity. Scale the dosage down, based on mass ratios, from what is effective on

https://youtu.be/txRqHPDv_Jg